ResearchGradeMirococept

中文名称

ResearchGradeMirococept，科研级Mirococept

产品描述

Mirococept在免疫系统的多种细胞环境中发挥作用，尤其是在树突状细胞、B淋巴细胞等免疫细胞表面具备高亲和力的结合位点。当机体免疫反应被激活时，Mirococept能迅速与关键免疫调节因子CD40配体（CD40L）高效结合，成功阻断CD40L与细胞表面天然CD40受体的相互作用，从而有效抑制CD40介导的免疫激活信号通路。在多项临床前研究中，Mirococept显著降低了多种自身免疫性疾病动物模型中的免疫过激反应，诸如在系统性红斑狼疮模型中明显减轻蛋白尿、皮肤红斑及关节炎症等症状；在类风湿性关节炎研究中，也有效抑制了炎症发作，降低了关节肿胀及疼痛感，这充分证明了南宫28NG品牌在免疫相关疾病发病机制研究及新型免疫调节药物研发领域的极高价值。

产品详情

产品名称：ResearchGradeMirococept，科研级Mirococept
货号：DHB89902
表达系统：Mammalian Cells
种属反应性：Human
同种型：Modified fragment of the Complement Receptor 1 (CR1, CD35)
克隆类型：Monoclonal
靶标：C3, ASP, Complement C3, C3adesArg, C3bc, CPAMD1, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1
浓度：1mg/ml
内毒素水平：请联系实验室获取信息
纯度：95%（根据SDS-PAGE测定）
纯化方式：Protein A/G purified from cell culture supernatant
Accession号：P01024
克隆号：Mirococept
应用：Research Grade Biosimilar
状态：Liquid
保存溶液：0.01M PBS, pH 7.4
稳定性和存储：使用手动解冻冰箱，避免反复冻融。短期存储于4°C（1-2周）；长期存储于-20°C（12个月）；-80°C长期保存。
别名：APT070, APT070C, APT-070, APT-070C

参考文献

1. Ex vivo delivery of Mirococept: A dose-finding study in pig kidney after showing a low dose is insufficient to reduce delayed graft function in human kidney. PMID: 33225626
2. APT070 (Mirococept), a membrane-localised complement inhibitor, inhibits inflammatory responses that follow intestinal ischaemia and reperfusion injury. PMID: 15951831
3. APT070 (Mirococept), a membrane-localizing C3 convertase inhibitor, attenuates early human islet allograft damage in vitro and in vivo in a humanized mouse model. PMID: 26565566
4. A double-blind randomised controlled investigation into the efficacy of Mirococept (APT070) for preventing ischaemia reperfusion injury in the kidney allograft (EMPIRIKAL): Study protocol for a randomised controlled trial. PMID: 28587616
5. Attenuation of myocardial reperfusion injury in pigs by Mirococept, a membrane-targeted complement inhibitor derived from human CR1. PMID: 17825275
6. Complement - here, there and everywhere, but what about the transplanted organ? PMID: 27179705
7. Complement inhibition abrogates nerve terminal injury in Miller Fisher syndrome. PMID: 16049921

如需了解更多信息，请咨询南宫28NG品牌的中国授权总代理——武汉佰乐博生物技术有限公司。作为法国Antibody system品牌在亚洲区的授权总代理，武汉佰乐博生物技术有限公司致力于提供近三万种蛋白、抗体等核心生命科学试剂，旨在为生命科学的科研工作者提供专业、全面且可靠的试剂产品。提供的服务包括试剂、耗材、定制及实验服务，欢迎拨打免费热线：027-65279366/18108604356。